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Screen On Cancer
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Conventionally there are 3 methods of tumor diagnosis:

Imaging method
Imaging techniques such as X-ray, CT Scan are widely used in cancer detection. One major advantage of this type of method is its ability to locate the tumor in the body. However, such techniques have its limitations as well. Not all cancers can be detected using X-ray or CT Scan.

Pathological method
This method is used for cancer diagnosis. However, it is invasive because it requires biopsy for examination. In addition, the tumor has to be located first mostly by imaging techniques before biopsy is taken for pathological examination.

Biochemical method
Biochemical method measures tumor markers and predicts the development of tumor based on marker concentration. However, no single tumor marker is sensitive or specific enough for tumor detection. Combined measurement of multiple tumor markers such as Biomarkers C12 is being adopted for more accurate detection of tumors in recent years.

Biochip technology is most suitable for simultaneous detection of multiple tumor markers. Biomarkers C12 has been developed for multi-tumor detection, which can analyze 12 tumor markers commonly tested in clinical laboratories. Biomarkers C12 has high sensitivity and high throughput capacity, and thus is expecially useful for cancer screen in high-risk and subclinical populations as well as in physical check-ups.

The mechanism of Biomarkers C12 Protein Chip for multi-tumor detection

Biomarkers 12 is based on specific binding of antigens to antibodies. Multiple antibodies are immobilized on a solid matrix, to capture the specific tumor markers in serum samples. The concentrations of tumor markers are determined quantitatively through chemiluminescent mechanism.

Diagram showing how Biomarkers C12 Protein Chip works


Biochip can be divided into three categories: DNA Chip, Protein Chip and Lab-on-a-chip. A DNA Chip contains up to thousands of short DNA probes attached to a surface and detects signals by hybridizing with the labeled DNA fragments. DNA Chip is for capable of measuring information of thousands of genes simultaneously, and it has been applied to searching new gene, sequencing, detecting mutation, analyzing polymorphism, measuring the extession level of genes and structuring the cDNA library.

Protein Chip is to detect protein interactions. It is closer to life activity than DNA Chip, so Protein Chip are of great potential in clinical diagnosis.
Lab-on-a-chip is the final object in the development of biochip technology. It integrates samle preparation, interaction, signal detection and analysis into one micro system. Lab-on-a-chip is still in the early stage of development.

The protein Chip System for Multi-tumor Marker Detection Biomarkers C12 is based on the capacity of parallel analysis of biochip technology and the principles of immunoassay to detect 12 tumor markers from many samples simultaneously.

Protein Chip System for Multi-Tumor Marker Detection